non-reversible       
adjective (also nonreversible) uk/ˌnɒn.rɪˈvɜː.sə.bəl/ us/ˌnɑːn.rɪˈvɝː.sə.bəl/
 不可逆的;不可逆转的
If something is non-reversible, it cannot be changed back to what it was before.
  The child has a non-reversible form of deafness.
 Evolution is a non-reversible process. 进化是一个不可逆的过程。 
 - More examples
 - The president declared that the lifetime ban on players who had taken drugs was non-reversible.
 - She has a disabling and non-reversible kidney disease.
 - The decision to withdraw from this year's tournament is non-reversible.
 - They could not find out what the password was because it had been stored using non-reversible encryption.