insanity          
noun [ U ] uk/ɪnˈsæn.ə.ti/ us/ɪnˈsæn.ə.t̬i/
 精神错乱,精神失常
the condition of being seriously mentally ill
  He was found not guilty of murder by reason of insanity. 他因为精神失常而未被判犯有杀人罪。 
 He suffered from periodic bouts of insanity. 他患有周期性精神失常。 
  疯狂;失去理智
an action that is stupid and likely to have extremely bad results
  It would be insanity to expand the business now. 现在扩大经营规模简直是疯了。