alienate  
verb [ T ] uk/ˈeɪ.li.ə.neɪt/ us/ˈeɪ.li.ə.neɪt/
  (LOSE SUPPORT)      
  离间;使背离;使不友好
to cause someone or a group of people to stop supporting and agreeing with you
  All these changes to the newspaper have alienated its traditional readers. 报纸改头换面疏远了老读者。 
   (MAKE UNWELCOME)      
 使格格不入;使疏远
to make someone feel that they are different and not part of a group
  Disagreements can alienate teenagers from their families. 家庭争吵会使青少年跟家人产生感情裂痕。