irreparably       
adverb uk/ɪˈrep.ər.ə.bli/ us/ɪˈrep.ər.ə.bli/
 不能修复地,无可挽救地
in a way that is impossible to repair or make right again
  The ship has been irreparably damaged. 这艘船已经受到不可修复的损坏。 
 She had broken his heart irreparably. 她已经无可挽回地伤了他的心。 
 See: irreparable
 - More examples
 - The incident irreparably harmed his reputation in the small town.
 - After her death, family life was irreparably altered.
 - They are planning a 20-year project that will irreparably affect the community.