world-weariness       
noun [ U ] uk/ˈwɜːldˌwɪə.ri.nəs/ us/ˈwɝːldˌwɪr.i.nəs/
 厌世,厌弃人生
a lack of enthusiasm, often because you have a lot of experience of life
  There is an air of world-weariness and dejection about him. 他的神态中带着厌世和颓废。 
 He was staring at her with a world-weariness suggesting he'd heard her argument a hundred times. 他带着厌倦的神情盯着她——说明他已经听过无数次她的论点了。 
 See: world-weary
 - More examples
 - Chris carries a world-weariness in his face and his posture.
 - Fleming's Bond has a dark streak of world-weariness and melancholy we never get to see on screen.
 - Even in the slump of his shoulders we can see the world-weariness of the man.