sadly  
adverb uk/ˈsæd.li/ us/ˈsæd.li/
  (NOT HAPPY)      
 B2 伤心地,悲伤地
in an unhappy way
  "He's gone away for six months," she said sadly. “他已经走了6个月了,”她伤心地说。 
 - More examples
 - She will be sadly missed by all who knew her.
 - "I just miss him." she said sadly.
 - "I want my Daddy back." he said, sadly.
 - He shook his head sadly.
 - Sadly, she didn't live that long.
 
  (UNPLEASANT)      
B2 令人遗憾地,令人伤心地
in a way that is not satisfactory
  Sadly, the treatment doesn't work for all patients. 很遗憾,这种治疗并不是对所有的患者都有效。 
 If you think she'll let you do that, you're sadly (= completely) mistaken. 如果你认为她会让你那么做,你就大错特错了。 
 - More examples
 - He is sadly lacking in social graces .
 - Enthusiasm has been sadly lacking these past months at work.
 - Sadly, the job wasn't suitable.
 - Sadly, this didn't solve the problem.
 - He had money but sadly no brains to speak of.