disabling       
adjective uk/dɪˈseɪ.blɪŋ/ us/dɪˈseɪ.blɪŋ/
 使某人丧失能力; 使某人伤残
(of an illness, injury, or condition) making it difficult for someone to do the things that other people do
  a disabling illness 致残性疾病 
 He suffered a serious, permanent and disabling head injury. 他头部遭受了严重的永久性损伤。 
 See: disable
 - More examples
 - About one-sixth of women in menopause experience at least five disabling hot flashes a day.
 - patients with life-threatening or disabling diseases
 - Most who suffer don't even seek treatment until the disorder has become disabling.